Thursday, 27 June 2013

Inspirational Ballard writer cracks New York Times bestseller list ...

Picture 5

Local writer Ingrid Ricks is one inspirational and successful Ballardite. The local Mom of two has hit number 20 on the New York Times bestseller list with her self published coming-of-age memoir,?Hippie Boy. The My Ballard team had the pleasure of sitting down with Ricks to chat about her writing career and the path that led her to where she is today.

Ricks is one tough cookie with an inspirational story and message to boot. In 2004, she was diagnosed with?Retinitis Pigmentosa Diagnosis, a?degenerative eye disease that, over time, is slowly stealing her eyesight. ?When I was diagnosed I was?devastated,? says Ricks. ?I was terrified of being a burden to my husband and my family?. It was then that the former journalist was sent to Africa to cover an AIDS story for the African Children?s Choir, which put everything into perspective and gave her the determination to live her life to the full. After the trip, instead of wallowing in self pity Ricks got up, dusted herself off and and, she puts it, gave herself permission to go after her dreams.

In terms of those dreams, she had always wanted to write a memoir about her childhood. So, in 2009 she started memoir writing classes and building her knowledge of writing narrative non-fiction. However, Ricks was still on the edge of embarking on the project that she had longed to start for many years until her daughters gave her the final push. ?We were walking down the street and my daughters bent over pretending to walk with a cane and said ?My book, my book I have to finish my book,? remembers Ricks. While at that exact moment she felt upset and bit her lip to stop from crying, she knew that this push was exactly what she needed to give herself permission to embark on fulfilling one of her dreams.

The realization of that dream was complete when, in October 2011, Ricks launched her self-published memoir Hippie Boy: A Girl?s Story.?The memoir tells the story of her life growing up with a devoutly Mormon mother and step-father and her experiences of finding her own voice and life along the way. Since self-publishing?Hippie Boy,?and having the story shared on NPR?s Snap Judgement,?Ricks has continued to realize her dreams publishing two more memoirs,?Focus?and?A Little Book of Mormon (or not so Mormon) Stories.?

On top of writing and self-publishing her memoirs, Ricks has also been busy inspiring youth to find their voice and power through writing. In 2012, Ricks co-founded a teen mentoring/publishing program at Scriber Lake High School in Edmonds with teacher?Marjie Bowker. Ricks and Bowker collaborated on the project and used?Hippie Boy as a guide for a month long course to empower students through writing. At the end of the course emotions ran high at a reading where the students shared the stories that they had written about their own lives. From there the program expanded, allowing the teens to write and publish their own stories, culminating in a published story collection We Are Absolutely Not Ok. Ricks and Bowker then launched a website?to facilitate teens helping teens through storytelling. The program is still in full swing, with funding on the way, and has been featured in Reader?s Digest, in The Seattle Times?and on King 5?s New Day Northwest. ?We want to have a spotlight on the serious issues that teens face,? says Ricks. ?It?s?been life changing for some of the teens involved.?

If you thought that between writing, self-publishing and co-founding a teen mentor program that Ricks would not have time for more, you thought wrong. Throughout this whole experience Ricks has been trying to build awareness about?Retinitis Pigmentosa Diagnosis and share her personal story through her blog Determined to See.com. On the blog Ricks shares her experiences, treatments that she has tried and generally promotes the message to embrace all that life has to offer. ?Life is short, embrace the moment,? says Ricks.

In terms of advice to others who are facing?Retinitis Pigmentosa Diagnosis, Ricks points to one important thing. ?I never thought it would come down to something as simple as diet. Focus on diet and lifestyle,? says Ricks. She points to following the alkaline based diet coined by Kris Carr in her book Crazy, Sexy, Diet.

Ricks is an inspirational and passionate person who we are sure to hear more from in the future. She inspires others through her writing, speaking and general outlook on life. So, to sum it all up, in the words of Ricks, ?when you really go after your dreams and give them everything you?ve got, the Universe has a way of making them happen.?

Photo courtesy of ingridricks.com.

Source: http://www.myballard.com/2013/06/26/inspirational-ballard-writer-cracks-new-york-times-bestseller-list/

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S.Africa's CPI expectations steady at 6 pct for 2013

JOHANNESBURG (Reuters) - South Africa's average inflation expectations in the second quarter were unchanged at 6.0 percent for 2013 compared with the first quarter, a survey showed on Thursday.

The Bureau for Economic Research inflation expectations survey, conducted for the South African Reserve Bank, showed expectations for 2014 rose to 6.1 percent in the second quarter, from 6 percent in Q1.

Source: http://news.yahoo.com/africas-cpi-expectations-steady-6-pct-2013-133101679.html

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UCLA wins championship with 8-0 win over Bulldogs

UCLA players pile up after defeating Mississippi State 8-0 in Game 2 to win the championship in the NCAA College World Series baseball finals Tuesday, June 25, 2013, in Omaha, Neb. (AP Photo/Nati Harnik)

UCLA players pile up after defeating Mississippi State 8-0 in Game 2 to win the championship in the NCAA College World Series baseball finals Tuesday, June 25, 2013, in Omaha, Neb. (AP Photo/Nati Harnik)

UCLA's Pat Valaika is tagged out at third base by Mississippi State third baseman Sam Frost on a single by Pat Gallagher in the first inning of Game 2 in their NCAA College World Series baseball finals, Tuesday, June 25, 2013, in Omaha, Neb. (AP Photo/Eric Francis)

UCLA starting pitcher Nick Vander Tuig throws against Mississippi State in the first inning of Game 2 in their NCAA College World Series baseball finals, Tuesday, June 25, 2013, in Omaha, Neb. (AP Photo/Eric Francis)

UCLA's Cody Regis (18) celebrates his run with teammate Eric Filia in the fourth inning of Game 2 in their NCAA College World Series baseball finals against Mississippi State, Tuesday, June 25, 2013, in Omaha, Neb. (AP Photo/Eric Francis)

UCLA's Brian Carroll, right, scores at home plate ahead of the throw to Mississippi State catcher Nick Ammirati on a single by Eric Filia in the first inning of Game 2 in their NCAA College World Series baseball finals, Tuesday, June 25, 2013, in Omaha, Neb. (AP Photo/Ted Kirk)

(AP) ? UCLA finally can add baseball to its long list of national championships.

The Bruins relied on pitching and defense to get them in position to win a title, and Tuesday night the offense finally showed up. Their 8-0 victory over Mississippi State gave them a two-game sweep in the College World Series finals.

"I don't think any of the experts thought we'd be here at this stage, and we did it the right way," coach John Savage said. "We pitched, we defended, we had quality offense, opportunistic offense for sure, and at the end of the day we outlasted everybody."

Eric Filia drove in a career-high five runs, Nick Vander Tuig limited Mississippi State to five hits in eight innings, and UCLA (49-17) increased its NCAA-record number of national championships in team sports to 109.

"They had a great year," Savage said of his players, "and it was one of those situations where it was our time."

Adam Plutko, the Bruins' No. 1 starter, was chosen the CWS Most Outstanding Player. He beat LSU in the Bruins' first game and was the winner in Game 1 of the finals. He allowed two runs in 13 innings.

Vander Tuig held off the Bulldogs (51-20) when they threatened in the fourth, fifth and eighth innings and recorded his fourth win in the NCAA tournament. Vander Tuig (14-4) struck out six and walked one. David Berg pitched the ninth.

Filia produced runs with a sacrifice fly, squeeze bunt and two base hits as the Bruins collected 12 hits and scored their most runs in 18 games.

"To beat us like they did today, and to do what they did to our pitching staff, which I think is one of the best in the nation," Bulldogs right fielder Hunter Renfroe said, "we didn't do what we were supposed to do. We didn't put up run support like we should have."

Bulldogs starter Luis Pollorena (6-4) lasted one inning. Jonathan Holder, the Bulldogs' closer, came on with one out in the fourth inning and went the rest of the way.

UCLA allowed four runs in five games to set a CWS record for fewest in the metal-bat era that started in 1974.

The Bruins' .227 batting average in the CWS also was the lowest since teams went away from wood bats. The Bruins' 19 runs in five games were the fewest by a champion since the CWS went to eight teams in 1950.

After Arizona's title last year, the Pac-12 has now won two straight and has 17 in all in baseball, most of any conference.

Mississippi State was playing for its first national title in a team sport and was the sixth straight Southeastern Conference team to make it to the finals.

"What we did was knock on the door, and UCLA has knocked on the door before and they knocked down the door, and we didn't do that," Bulldogs coach John Cohen said. "It bothered me we didn't play well the last two days. We played 15 postseason games and didn't play well in two of them."

Vander Tuig, who won his fourth straight postseason start, gave up just one earned run in 21 1-3 innings over his last three starts.

"I think back on all the experience I've had in three years and how it really helped me," Vander Tuig said. "I also think of just how many wins this team has had and the opportunities we've had. It's what has gotten me to where I am, trying to keep things simple, making pitches and letting my defense work."

The Bruins won their first title in their third CWS appearance in four years and fifth all-time. They had made it to the finals in 2010 and were swept by South Carolina. Last year they went 1-2 in Omaha.

This season they finished third in the Pac-12, behind Oregon State and Oregon, and then got hot in the postseason.

They made magic with an offense that started Tuesday 264th out of 296 teams in batting (.247) and 215th in scoring (4.7 runs per game), but among the national leaders in sacrifices, walks and hit batsmen.

UCLA won three straight at home in regionals and went on the road to upset No. 5 national seed Cal State Fullerton in a two-game super regional.

Once the Bruins got to Omaha, they made themselves at home in spacious TD Ameritrade Park. UCLA produced just enough offense to support its superb pitching and defense in bracket play, and again in Game 1 of the finals.

The pitching and defense showed up again in Game 2, and this time so did the offense.

"We've been capable all season long," Savage said. "We have good players. I said that all along. They started to believe, and they used the whole field. Fortunately, we had some hits tonight."

UCLA was up three runs early ? a lead that has been insurmountable for every team in this year's CWS.

The Bruins used a hit batsman, a bunt that produced two Mississippi State errors, and Filia's sacrifice fly to lead 1-0 in the first. It was 3-0 in the third after Brian Carroll scored on a safety squeeze bunt by Filia and Pat Valaika's RBI single.

By the time the Bulldogs were forced to call on Holder, it was pretty much game over.

"As far as Mississippi State goes, they'll be back," Bulldogs shortstop Adam Frazier said. "Coach Cohen is doing the right things, the coaching staff has it going in the right direction. I trust coach Cohen will get it to what it is supposed to be, and I've got a feeling this team will be back in the future."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-06-26-CWS%20Finals/id-7c8c7bd50ec849af87181c86e6ef894b

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In Canada and prefer buying your iPads from carriers rather than Apple? TELUS and Rogers now have you covered!

TELUS and Rogers now selling iPad 4 and iPad mini directly to customers

Starting today, Canadian carriers TELUS and Rogers will offer the cellular versions of both the iPad 4 and the iPad mini directly to customers for use on their respective networks. Rogers will allow customers to add it to their existing cellular plan, and while TELUS did not mention if that will be available on their network, both carriers will offer customers the option of a separate, contract-free data plan for their device. In a press release TELUS said that they will also offer sharing plans as well as giving customers the opportunity to pay a low upfront price.

TELUS is offering a number of simple data and payment plans providing its customers with the freedom and convenience to share data with family members across multiple devices on the same account. With the TELUS Easy Tablet program, customers can purchase their new tablet for a low upfront price and pay off the remaining balance over a set term in equal monthly payments.

The cellular versions of both the iPad 4 and iPad mini have been available for use on these carriers, but this is the first time they are being offered directly by either. TELUS appears to only be selling the 16 and 32GB version of both iPad models, excluding the 64GB of both, as well as the 128GB version of the iPad 4. Rogers, meanwhile, appears to be selling every version of both devices.

It's hard to imagine Bell won't get in on the action soon too, so if they're you're go to, stay tuned...

Source: Rogers, PRNewsWire

    


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/q6zBv86prIk/story01.htm

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Monday, 24 June 2013

Samsung Galaxy Tab 3 series hits the U.S. on July 7

Galaxy Tab 3

7, 8 and 10.1-inch Tab 3 variants heading stateside, pre-orders begin tomorrow

Already announced internationally, Samsung's Galaxy Tab 3 series will be heading to the United States in a couple of weeks. The 10.1, 8 and 7-inch tablets go up for pre-order tomorrow, and begin shipping on July 7. In its latest line-up of Android-powered tablets, the Korean manufacturer has scaled things back a bit, focusing on affordable, thin, light devices for the mass market.

read more

    


Source: http://feedproxy.google.com/~r/androidcentral/~3/_njFtyQgBtE/story01.htm

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South Africans resigned over 'critical' Mandela

By Jon Herskovitz

JOHANNESBURG (Reuters) - South Africans adopted a mood of somber resignation on Monday to the inevitability of saying goodbye to former president Nelson Mandela after the 94-year-old anti-apartheid leader's condition in hospital deteriorated to critical.

Madiba, as he is affectionately known, is revered among most of South Africa's 53 million people as the architect of the 1994 transition to multi-racial democracy after three centuries of white domination.

However, his latest hospitalization - his fourth in six months - has reinforced a realization that the father of the post-apartheid 'Rainbow Nation' will not be around for ever.

President Jacob Zuma, who visited Mandela late on Sunday with African National Congress (ANC) Deputy President Cyril Ramaphosa, reflected the national mood when he told a news conference that Mandela remained critical.

"All of us in the country must accept that Madiba is now old. As he ages, his health will trouble him," Zuma said, declining to give specific details about Mandela's medical condition or other information from his hospital visit.

"Given the hour, he was already asleep. We saw him, looked at him and then we had a bit of a discussion with the doctors and his wife," Zuma said. "I don't think I'm a position to give further details. I'm not a doctor."

U.S. President Barack Obama is due to visit South Africa this week as part of a three-country Africa tour but Zuma said Mandela's worsening state of health should not affect the trip.

"Nothing is going to stop the visit because Madiba is sick," Zuma said.

"WE WILL MISS HIM"

Mandela's deterioration this weekend, two weeks after being admitted in a serious but stable condition with a lung infection, has caused a perceptible switch in mood from prayers for recovery to preparations for a fond farewell.

"If it's his time to go, he can go. I wish God can look after him," said nurse Petunia Mafuyeka, as she headed to work in Johannesburg.

"We will miss him very much. He fought for us to give us freedom. We will remember him every day. When he goes I will cry."

There was some concern among the public about doctors trying to prolong the life of South Africa's first black president, one of the 20th Century's most influential figures.

"I'm worried that they're keeping him alive. I feel they should let him go," said Doris Lekalakala, a claims manager. "The man is old. Let nature take its course. He must just rest."

Since stepping down in 1999 after one term as president, Mandela has stayed out of active politics in a country with the continent's biggest and most important economy. His passing is expected to have little political impact.

His last public appearance was waving to fans from the back of a golf cart before the final of the soccer World Cup in Johannesburg's Soccer City stadium in July 2010.

During his retirement, he has divided his time between his home in the wealthy Johannesburg suburb of Houghton, and Qunu, the village in the poor Eastern Cape province where he was born.

The public's last glimpse of him was a brief clip aired by state television in April during a visit to his home by Zuma and other senior ANC officials.

At the time, the 101-year-old liberation movement, which led the fight against white-minority rule, assured the public Mandela was "in good shape", although the footage showed a thin and frail old man sitting expressionless in an armchair.

(Additional reporting by Pascal Fletcher; Writing by Ed Cropley; Editing by Pascal Fletcher and Angus MacSwan)

Source: http://news.yahoo.com/south-africans-resigned-over-critical-mandela-060437497.html

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Sunday, 23 June 2013

AP Source: Clippers land new coach in Doc Rivers

(AP) ? A Boston Celtics official tells The Associated Press that a deal to allow Doc Rivers to coach the Los Angeles Clippers has been agreed to.

The official spoke on the condition of anonymity because the deal was contingent on NBA approval and negotiations between Rivers and the Clippers over a new contract.

Rivers had three years and $21 million remaining on his deal with the Celtics, but he has expressed reluctance to coach through a rebuilding process. The 2008 NBA champions appear to be headed for one after losing in the first round of the playoffs this season.

The teams were also discussing a deal that would send Kevin Garnett to the Clippers, but NBA commissioner David Stern said he wouldn't approve a deal in which coaches were traded for active players.

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/347875155d53465d95cec892aeb06419/Article_2013-06-23-BKN-Clippers-Rivers-/id-9c90dd2fe1484456b302030a45d8dd16

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Southwest flights delayed, canceled after computer glitch

(Reuters) - Southwest Airlines Co canceled or delayed about 250 flights overnight and early on Saturday due to a system-wide outage of computers used to dispatch aircraft, said a spokeswoman for the airline.

The Dallas-based airline said 43 overnight flights were canceled as a result of the outage, which began around 11 p.m. EDT on Friday (0300 GMT on Saturday) and lasted until about 3 a.m. on Saturday (0700 GMT), said Southwest Airlines spokeswoman Michelle Agnew.

Another 14 morning flights were canceled due to "flight crew availability and aircraft positioning" after the outage ended, she said.

Most of the cancellations affected routes in the western United States, Agnew said. Flights that were already airborne were not affected by the outage, while planes on the ground were held back, she said, adding that the cause of the computer failure was unknown.

Southwest, which operates some 3,400 flights daily, said in a statement on its website that its "systems are working at full capacity."

(Reporting by Eric M. Johnson; Editing by Scott Malone and Paul Simao)

Source: http://news.yahoo.com/southwest-flights-delayed-canceled-computer-glitch-144202486.html

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5 Ways to Improve Your Relationship Right Now! | World of ...

5 Ways to Improve Your Relationship Right Now!All relationships ? even the best ones ? require continuous care and hard work. But that doesn?t necessarily mean taking big actions or making dramatic changes.

Little tweaks also can be tremendously helpful. That?s because simple, everyday positive behaviors add up. Don?t believe us? Give these a try and you may be surprised.

Below, Julie Orlov, MSW, a psychotherapist and author of the book?The Pathway to Love, shared five ways you can instantly improve your relationship.

1. Focus on what you love about your partner.

After spending years together and dealing with day-to-day stressors, couples can forget to focus on the positive. Relationships can easily become a litany of ?you didn?t do this? or ?stop doing that.?

That?s why Orlov suggested reminding yourself ?what it was that made you fall in love with your spouse.? Focus on the qualities you appreciate. ?And don?t forget to share those thoughts with your spouse.?

2. Touch your partner.

?When you have physical contact, it is harder to remain closed off, angry and disconnected.? Just touching your partner or giving them a hug can go a long way in connecting you as a couple, Orlov said. ?

3. Listen to your partner.

Take the time to listen to what?s important to your partner. According to Orlov, ?if your spouse has something to say to you about their feelings, needs, reaction or wants, it behooves you to truly listen rather than respond with either your own opinion or defensiveness to what they said.?

That?s because once you put down your defenses and stop rehearsing your own responses in your head, you?ll be able to gain a clearer and deeper understanding of your partner, and your relationship.

4. Find the humor in a situation.

Humor heals. It provides us with perspective. ?Laughter also releases a lot of stress, allowing more positive feelings to ensue,? Orlov said. Try to find the light side of a situation, and laugh together.

5. Get intimate.

?When you connect in a way that is sacred to your relationship alone, you can?t help but feel more intimate and connected,? Orlov said. Plus, the release of feel-good chemicals also enhances your love and attachment, she said.

Relationships require regular maintenance, and the above tips can help you build a healthy, meaningful bond. Often, it?s the small steps, taken every day, that can make a big, positive difference in cultivating your connection.

?

Margarita TartakovskyMargarita Tartakovsky, M.S. is an Associate Editor at Psych Central and blogs regularly about eating and self-image issues on her own blog, Weightless.

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Catch up on other posts by Margarita Tartakovsky, M.S. (or subscribe to their feed).



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????Published on PsychCentral.com. All rights reserved.

APA Reference
Tartakovsky, M. (2013). 5 Ways to Improve Your Relationship Right Now!. Psych Central. Retrieved on June 23, 2013, from http://psychcentral.com/blog/archives/2013/06/22/5-ways-to-improve-your-relationship-right-now/

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Source: http://psychcentral.com/blog/archives/2013/06/22/5-ways-to-improve-your-relationship-right-now/

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Medtronic takes 'first step' toward U.S. sale of artificial pancreas

By Julie Steenhuysen

CHICAGO (Reuters) - Type 1 diabetics, who run the risk of dangerously low blood sugar, may be a step closer to getting help from a crude artificial pancreas device that can read blood sugar levels and automatically turn off the flow of insulin after a clinical trial showed the device is safe.

The long-awaited results of the clinical trial may pave the way for U.S. approval of the device, made by Medtronic, which already sells insulin pumps with an automatic shutoff feature in 50 countries outside the United States. The feature is meant to guard against delivering insulin to diabetics their blood sugar is already too low.

As many as 3 million Americans have type 1 diabetes, in which the immune system destroys cells in the pancreas that make insulin.

Type 1 diabetes must monitor their blood sugar and take insulin several times a day. Too little insulin can cause high blood sugar, increasing the risk of long-term complications such as eye damage, kidney failure and heart disease. But too much insulin can cause blood sugar to drop too low, causing hypoglycemia, which can result in seizures, unconsciousness, brain damage and death.

U.S. regulators have refused to allow insulin pumps with an automatic shutoff feature on the U.S. market without a large, carefully controlled clinical trial proving they are safe.

The latest study, known as ASPIRE, which tested the system in 247 people with diabetes in their homes, offered the proof.

It showed the device reduced the amount of time and the duration that a diabetic's blood sugar fell below a certain threshold - a measure known as area under the curve - by 37.5 percent. The device reduced the overall number of low blood sugar episodes by 31.8 percent compared to diabetics using an insulin pump without the shutoff feature.

The findings were published online on Saturday in the New England Journal of Medicine and presented at the American Diabetes Association meeting in Chicago.

Dr. Francine Kaufman, vice president of global medical affairs for Medtronic's diabetes business, said the study showed that shutting off the flow of insulin mimics what happens in healthy people in response to low blood sugar.

Kaufman, a pediatric endocrinologist who still has an active practice in Los Angeles, said the device is intended to help diabetics who may find themselves in a situation where they cannot help themselves.

"Many of my patients are 3 years old. So, if mom is not around, they don't know how to do this on their own," she said. "We're going to take that and automate it for them."

Dr Richard Bergenstal, of the International Diabetes Center at Park Nicollet Health Services in Minneapolis, the study's lead author, highlighted the study's findings.

"That is a significant reduction in the duration and severity of low blood sugar," he told a news briefing at the diabetes meeting.

'HOLY GRAIL'

Diabetes advocates, researchers and medical device companies for decades have spoken wistfully about the "holy grail" of an artificial pancreas, a complex system of pumps and sensors aimed at automating the complex care and treatment of type 1 diabetes by mimicking the function of a real pancreas.

The Medtronic device is decidedly not that. But it is the first device before the U.S. Food and Drug Administration to detect dangerous blood sugar levels and automatically take action to correct it.

"The study results are important as we continue to move toward our goal of developing a fully automated system, or artificial pancreas, that will one day require very minimal interaction from the patient," Medtronic's Kaufman said.

In designing the study, researchers had to find a population of patients who were especially prone to having hypoglycemia at night. Bergenstal said as many as 320 people tried to enroll in the study, but only 247 qualified.

'THEY DIDN'T WAKE UP'

Spears Mallis, a 34-year-old administrator for the Longstreet Cancer Center in Gainesville, Georgia, was one.

Mallis, an avid runner, has had type 1 diabetes for almost 17 years. For the past 16 or so, he has used an insulin pump, often pared with a continuous glucose monitor, to keep track of his blood sugar and deliver a steady flow of insulin.

But Mallis still suffers from occasional bouts of hypoglycemia, which were especially disturbing when he had a job that required him to travel.

Like many in the diabetes community, Mallis was aware of efforts several years ago by the Juvenile Diabetes Research Foundation and others to push the FDA to set guidelines for approving the Medtronic device. Some had even hoped the agency would allow these devices on the U.S. market without additional testing. But in 2011, the FDA made clear the company would need a clinical trial, and Mallis was on board.

During the three-month trial, Mallis said the suspend device kicked in several times. "In one of my races, it went off and I had it go straight to suspend."

He said the device's alarm feature was loud enough to wake his wife, but there were times he would sleep through it. "After you have type 1 diabetes for awhile, your senses become lessened for feeling low blood sugar."

Mallis said the device would stop the flow of insulin until he woke and took action himself.

His experience was typical. Bergenstal said for many individuals, the device was suspended for the full two-hour maximum, despite the alarm. "They didn't wake up."

The study was also designed to see if cutting off insulin for this period would cause insulin to "rocket back up," Bergenstal said. But at the end of the two-hour period, it just "gradually drifted back up into the normal range," he said.

The study also showed the device had no impact on a measure of long-term control of blood sugar called A1c.

Kaufman said Medtronic has presented the study results to the FDA and received an approvable letter for its next-generation pump device that includes the feature, meaning the device can be approved provided the company meets certain conditions. Chief Executive Omar Ishrak has said he expects device approval during the current calendar year.

"We are just going back and forth on overall quality issues. We're working very collaboratively with FDA to work through some of the issues," Kaufman said.

Meanwhile, the company and its rivals, including Johnson & Johnson's Animas unit, are working on next-generation devices that add more automated features.

On Friday, the company presented results at the diabetes meeting on a study of a system designed to predict when diabetics are heading for a dangerous low and take preemptive action by decreasing the amount of insulin the pump delivers.

The night-time study of 20 adults with type 1 diabetes showed the software control program helped people stay within a target range for 90 percent of the time.

Ramakrishna Venugopalan, director for research and development at Animas, sees the development of an artificial pancreas as a step-wise process, in which products begin to automate more and more of the functions now managed by patients.

The company this month won approval for another feasibility study, its third in three years.

Venugopalan still can't say when a fully automated artificial pancreas will be available, but adds, "I don't think this is a pipe dream."

(Reporting by Julie Steenhuysen; Editing by Michele Gershberg and Leslie Adler)

Source: http://news.yahoo.com/medtronic-takes-first-step-toward-u-sale-artificial-150641948.html

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Singapore to Indonesia: Stop sending us your smog.

Air pollution in Singapore?rose to unhealthy levels this week because of illegal forest clearing in Indonesia,?prompting?Singapore?to urge Indonesia to do something to end the haze.

By Sara Schonhardt,?Correspondent / June 20, 2013

A masked man walks as the sun sets among buildings covered with haze at the Singapore Central Business District Thursday, June 20, 2013. Singapore urged people to remain indoors amid unprecedented levels of air pollution Thursday as a smoky haze wrought by forest fires in neighboring Indonesia worsened dramatically.

Joseph Nair/AP

Enlarge

Cloudy skies in Jakarta were no match for the breathtaking haze that hit Singapore?on Thursday?as air-pollution levels rose to record highs and sparked a war of words between diplomats in both countries over who should shoulder the blame.

Skip to next paragraph Sara Schonhardt

Indonesia Correspondent

Sara Schonhardt is a Monitor contributor based in Jakarta, Indonesia, where she has been reporting since 2009.?Sara previously worked for various media in Thailand and Cambodia and received her master?s degree from the School of International and Public Affairs at Columbia University.

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Companies have asked employees to work from home, the military has stopped training outdoors, and pictures of Singapore's iconic Marine Bay Sands towers barely visible through the haze have been splashed across social media platforms?and newspapers.

Despite the international blame game, the immediate cause was clear enough: fires used to clear land in Sumatra for farming and palm oil plantations. A local meteorological agency reported nearly 150 hotspots alone in Riau Province, itself a hotspot for mining, logging, and palm oil production.

Environmental advocacy group Greenpeace released a statement saying that the fires illustrated how Indonesia?s government policies aimed at reducing deforestation had failed?since half of them were in areas off-limits to land clearing.

Each year slash and burn practices in Indonesia shroud neighboring Singapore and Malaysia in thick haze. As deforestation has accelerated in recent years, it has worsened.

On Thursday,?Singapore sent a delegation from its environmental agency to Jakarta to call for immediate action.?Singapore?s environment minister, Vivian Balakrishnan, issued an angry statement?on his Facebook page saying no country or corporation ?has the right to pollute the air at the expense of Singaporeans? health and well-being.??

But Indonesia shot back its own statement: Singapore should stop ?behaving like a child,? said Indonesia?s?Coordinating Minister for People's Welfare, Agung Laksono, who oversees fire response.

Mr. Balakrishnan had asked the Indonesian government to name and shame the companies involved in the illegal burning. But Indonesia?s forestry ministry launched back, saying?Singapore and Malaysia shared the responsibility for putting pressure on the resource extraction industry since many of companies were based in their countries.

Source: http://rss.csmonitor.com/~r/csmonitor/globalnews/~3/DSOCJEKKLvY/Singapore-to-Indonesia-Stop-sending-us-your-smog

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Friday, 26 April 2013

Full Samsung Knox launch delayed until a 'later date'

Full launch of Samsung Knox delayed until a 'later date'

The Galaxy S 4 launch was also supposed to mark the release of Knox, Samsung's plan to balance home life and work through software. Unfortunately, Galaxy owners will have to live slightly off-kilter for a while longer -- the company has officially delayed full Knox service to a "later date." While the GS 4 ships with the necessary underpinnings, both distributors and providers have to fall into place before the suite is completely ready. Samsung hasn't officially said when it expects Knox to arrive in earnest, although the New York Times claims that it may appear as late as July. Whether or not that's true, the setback adds to what's becoming a hitch-prone debut for Samsung's 2013 Android flagship.

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Source: New York Times

Source: http://www.engadget.com/2013/04/24/full-launch-of-samsung-knox-delayed-until-a-later-date/?utm_medium=feed&utm_source=Feed_Classic&utm_campaign=Engadget

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Monday, 22 April 2013

Home is where the heart is: Facebook Home downloads top 500,000

April 22 (Reuters) - Pep Guardiola is not the only connection between Bayern Munich and Barcelona, who meet in their Champions League semi-final, first leg at the Allianz Arena on Tuesday. Both teams are dominating their leagues to an almost embarrassing extent, have won the Champions League four times apiece, share an acrimonious rivalry with Real Madrid, and owe part of their success to the flamboyant Dutchman Louis van Gaal. Both have also been in two Champions League finals in the last four years, though the Catalans won both of theirs and the Bavarians came out losers on each occasion. ...

Source: http://news.yahoo.com/home-where-heart-facebook-home-downloads-top-500-120044767.html

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5 dead in shooting south of Seattle

FEDERAL WAY, Wash. (AP) ? Gunfire erupted at an apartment complex in a city south of Seattle and five people were shot to death, including a suspect who was shot by arriving officers, police said early Monday.

Officers responding to an emergency call at 9:30 p.m. PDT Sunday at the apartments in Federal Way encountered a chaotic scene, with bullets flying.

"When officers arrived there were still shots being fired," said Federal Way police spokeswoman Cathy Schrock.

They found two wounded men on the ground in a parking lot. One of the men reached for a gun as police moved in to assist the two, she said.

At that point, officers opened fire. The suspect died but police said it wasn't immediately clear if it was from their gunfire.

The other man on the ground and a third man in the parking lot were found dead.

In a search of the complex, police found a fourth man dead in one apartment and a slain woman in another unit. Schrock said police were trying to determine if the woman was hit by a stray bullet.

A total of eight officers fired their weapons, Schrock said. All have been placed on administrative leave, per standard policy, as the investigation continues.

There was no immediate word what set off the shooting. Police scheduled a briefing for late Monday morning.

"We still don't have any idea what started this disturbance tonight," Schrock said.

After police flooded the area and carried out searches, authorities said they were confident there were no more casualties from the shooting.

They said they did not think another shooter was on the loose or that there was an immediate threat to the public.

There were no reports of any officers being injured, and the names of the five people who were killed were not immediately available.

Federal Way is about 20 miles south of Seattle.

Source: http://news.yahoo.com/police-5-dead-shooting-south-seattle-081054003.html

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Syrian opposition rejects extremism in nod to Western demands

By Mariam Karouny and Nick Tattersall

ISTANBUL (Reuters) - Syria's opposition outlined its vision for an era after President Bashar al-Assad on Sunday, rejecting "all forms of terrorism" and vowing to keep weapons out of the "wrong hands" in a nod to the demands of its Western backers.

After six hours of meetings in a palace on the shores of the Bosphorus in Istanbul, the declaration by the main opposition Syrian National Coalition was welcomed by allies including the United States and Britain.

U.S. Secretary of State John Kerry said Washington would double its non-lethal aid to opposition forces in Syria to $250 million and that foreign backers had agreed to channel all future assistance through the rebels' Supreme Military Council.

Speaking after the "Friends of Syria" meeting of the opposition and their international backers, Kerry stopped short of a U.S. pledge to supply weapons that the anti-Assad insurgents have sought.

But he said the rebels' foreign backers were committed to continuing support to them and "there would have to be further announcements about the kind of support that that might be in the days ahead" if Syrian government forces failed to pursue a peaceful solution.

The pledge is far less than what is sought by U.S. allies Britain and France and some U.S. lawmakers.

British Foreign Secretary William Hague said the European Union would in the coming weeks discuss easing an arms embargo which has prevented weapons supplies to the Syrian rebels. His German counterpart, Guido Westerwelle, said Berlin was skeptical about arming the rebels but also said the EU must discuss it.

The opposition declaration vowed any weapons it attains would not fall into the wrong hands, a key concern of its Western backers, and said its goal was a "democratic, pluralistic" Syria.

Syria's al-Nusra Front, one of the most effective rebel forces battling Assad's troops, formally pledged allegiance to al Qaeda leader Ayman al-Zawahri this month. The United States has designated the Nusra Front a terrorist organization.

"We realize that there are radical and extremist elements in Syria which follow an agenda of their own. We firmly reject and condemn all forms of terrorism and any extremist ideology or mentality, as do the Syrian people," it said.

The coalition pledged it would not allow acts of revenge against any group in Syria, saying that members of Assad's administration "with blood on their hands" would be held accountable through fair trials.

'CLEAREST LANGUAGE YET'

The Syrian conflict began more than two years ago as peaceful demonstrations against Assad's rule but gradually became militarized under a heavy crackdown by his forces.

A subsequent civil war pitted the Sunni majority against members of Assad's Alawite sect, an offshoot of Shi'ite Islam, in a conflict which has killed more than 70,000 people.

"Today, it's safe to say that we are really at a critical moment," Kerry said. "The stakes in Syria couldn't be more clear: Chemical weapons, the slaughter of people by ballistic missiles and other weapons of huge destruction."

The Syrian opposition's Western backers have been alarmed at the rise of radical Islamist groups like the al-Nusra Front in the insurgent ranks, who consider Alawites and Shi'ites as infidels.

"We will not tolerate or allow acts of revenge and retribution against any group in Syria," the opposition coalition said in its declaration.

Britain's Hague said the declaration was "the clearest language" yet from the opposition in renouncing radical groups and committing to a democratic solution.

The crisis in Syria has divided world powers, with the United States, Europe, Gulf states and Turkey backing the opposition, while Russia, Iran and others have backed Assad.

Opposition leader Moaz Alkhatib urged Russia to play a positive role "to stop the bloodshed" in an increasingly sectarian war that risks engulfing the region.

"We strongly call on Iran not to get involved more than it has and to pull out its officers," Alkhatib told a joint news conference with Kerry and Turkish Foreign Minister Ahmet Davutoglu.

"(Iran) also has to ask Hezbollah to pull out its fighters from Syria in order to avoid dragging the region to a bigger battle," he said.

The rebels accuse the Lebanese Shi'ite movement Hezbollah of sending fighters to support Assad's forces. Several members of Hezbollah have been killed in clashes in villages near the Syria-Lebanon border.

The Syrian opposition had hoped the Istanbul meeting would give teeth to a tacit agreement that arming rebel groups is the best way to end Assad's rule.

(Additional reporting by David Brunnstrom; Editing by Paul Simao)

Source: http://news.yahoo.com/syrian-opposition-rejects-extremism-nod-western-demands-003559751.html

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Source: http://soliloquize-hyde.blogspot.com/2013/04/proven-article-marketing-tips-writing.html

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Sunday, 21 April 2013

Pa. nurse says there was 'no justification' for killing 29 patients

TRENTON, N.J. (AP) ? At his sentencing hearings in 2006, serial killer nurse Charles Cullen did not explain why he killed at least 29 hospital and nursing home patients in New Jersey and Pennsylvania.

He had told investigators they were mercy killings. But a prosecutor said Cullen was driven by a compulsion to kill and was no "angel of death."

In an interview to be broadcast Sunday on CBS' "60 Minutes," Cullen at first says he thought he was helping people by ending their suffering. Many of the victims of his lethal drug overdoses were old or gravely ill.

But Cullen tells a different story when reminded some victims were not close to death. He says there was "no justification" and "I felt overwhelmed at the time."

Cullen is serving multiple life terms at the New Jersey State Prison in Trenton. He claimed to have killed 40 patients over a 16-year nursing career, but some experts on the case believe he had even more victims.

When asked if he was sorry for what he did, he said, "Yes."

But he also said that if he hadn't been caught, "I don't know if I would have stopped," according to excerpts of the interview provided by "60 Minutes."

Asked what his motivation was, Cullen said: "I thought that people weren't suffering anymore. So, in a sense, I thought I was helping."

But when reminded some were not close to death or in great pain, he said "there is no justification" and "the only think I can say is that I felt overwhelmed at the time."

Pressed further for an explanation for the families of the victims, he said, "It felt like I needed to do something and I did. And that's not an answer to anything."

Source: http://news.yahoo.com/nurse-backs-off-mercy-claim-29-nj-pa-153353471.html

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Saturday, 20 April 2013

Device to mitigate power outages, prevent equipment damage

Apr. 19, 2013 ? A local power failure in Ohio ten years ago caused a series of cascading power failures that resulted in a massive blackout that affected 50 million people and caused billions of dollars in damage and lost revenue.

Such blackouts could be prevented in the future, thanks to a new piece of equipment developed by engineering researchers at the University of Arkansas. The device regulates or limits the amount of excess current that moves through the power grid when a surge occurs.

"We didn't invent the fault current limiter," said Alan Mantooth, Distinguished Professor and executive director of the National Center for Reliable Electric Power Transmission, based at the university. "But we have developed the first one using a silicon-carbide semiconductor device and technology, which we have developed over the past five years. The significance of this material cannot be overestimated. It is much more durable and responds so much faster than materials currently used in systems on the U.S. power grid."

A fault current, also known as a surge, occurs when too much current flows through the electrical power grid in an uncontrolled manner. A fault current is typically caused by an accident or unintended event, such as lightning or contact between power lines and trees. These events cause short-circuits, which result in a rapid increase in the electricity drawn from power sources within the grid.

When these sources do not have extra power to give, cascading or rolling blackouts can occur. This is what happened in Ohio, much of the northeast United States and parts of Canada in 2003.

A fault current limiter can be thought of as a giant surge protector. When excess current travels through a power line, the limiter absorbs it and then sends only what is necessary farther down the line, Mantooth said. The system thus ensures uninterrupted service when the fault is intermittent. Most consumers would not even detect a problem. Furthermore, if the fault is more permanent and will require repair to power lines, Mantooth said, the device then opens much like a normal circuit breaker, which would thus prevent further damage due to excess current.

Proper coordination and device placement will prevent cascading outages, he said.

"This device really can mean the difference between 25,000 customers or 5 million customers being affected," Mantooth said.

The U of A researchers worked with silicon-carbide, a semiconducting material that is stronger and faster than conventional materials used in the power grid. High-speed switching devices within the limiter rapidly insert energy-absorbing impedance into the circuit or use advanced control techniques to limit the fault current, Mantooth said.

Silicon-carbide has other benefits as well. Its properties allow for extremely high voltage, and it is a good thermal conductor, which means that it can operate at high temperatures without requiring extra equipment to remove heat. Overall, use of the material will reduce the mass and volume of equipment needed on a power grid.

Mantooth envisions the device working in concert with circuit breakers on individual buildings, especially critical facilities such as hospitals. It could also serve neighborhoods, where one limiter could regulate current and thus preserve power for many houses. Depending on the size of the building or neighborhood, devices would vary in terms of amperage and voltage.

Mantooth said the U of A's system, and fault current limiters in general, are examples of devices that will make and serve a "smart" grid, meaning they will play an integral role in the U.S. Department of Energy's vision for a more efficient and more reliable power grid.

The National Center for Reliable Electric Power Transmission is funded as part of the federal government's focus on research and development on smart grid and renewable technologies. The center is one of only a few university-based research centers chosen by the Energy Department to investigate electronic systems to make the nation's power grid more reliable and efficient.

The Energy Department has funded the center since 2005 because of the university's research expertise in advanced power electronics and long-term investigation of silicon-carbide.

Mantooth is holder of the Twenty-First Century Chair in Mixed-Signal Integrated Circuit Design and Computer-Aided Design in the College of Engineering.

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Disclaimer: Views expressed in this article do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/matter_energy/technology/~3/9kQDcVYGYOc/130419094143.htm

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Friday, 19 April 2013

Ann Curry "Humilated" by Today Firing, Mocked by Producers for Fashion Choices

Source: http://www.thehollywoodgossip.com/2013/04/ann-curry-humilated-by-today-firing-mocked-by-producers-for-fash/

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Scientists puzzle over how bat brains and rat brains build mental maps

Alex Mita / AFP - Getty Images file

An Egyptian fruit bat flies in an abandoned quarry near the village of Mammari, west of Nicosia, in March 2007.

By Nidhi Subbaraman

At a lab at the Weizmann Institute of Science in Israel, fruit bats in a roomy cage flew circles around a metal rig that roughly resembles a tree. Electrodes on their head recorded and wirelessly transmitted a map of the electrical activity in their brain.?

Bats, like birds, are deviously good at finding their way over long distances. Egyptian fruit bats will?fly up to a hundred kilometers from their roosting cave to visit a favorite fruit tree. By studying the brain activity, researchers hoped to uncover clues about how many mammals, not just bats, know where they are ? how high up they are when they peek out of a 10th-story window, how far they need to leap so they can make it to the next branch, or how to make back it home once they've reached their favorite tree.?

Five thousand miles away, at Boston University, neuroscientists sought answers to some of the same questions. They tracked electric signals in slices of rat and bat brain tissue for evidence of certain rhythmic electrical pings. Such pings have been thought to play a?key role in navigation and space awareness.?

Months later, these readings from both the flying bats and the "cold cut" slices of brain tissue are now challenging one of the leading explanations for how mammalian brains interpret the space around them. The new findings indicate?that the rhythmic firing of neurons ? a feature frequently found in brain-wave scans for all kinds of mammals ? may not play as central a role in understanding space as previously thought. Two papers?describing the work appear in Friday's issue of the journal Science.?

Nachum Ulanovsky, a neuroscientist at the Weizmann Institute and one of the flying bat watchers, was tracking signals from the hippocampus, the part of the brain that deals with spatial memory and is understood to play a key role in navigation.?

Hippocampal neurons discovered in the 1970s help bats and other mammals map a new space, he explained to NBC News. When these neurons, known as "place cells," were tracked in a rat's brain, each location of the room activated a different and specific group of cells. Place cells are fed information from "grid cells," which have ?been observed at work in various moving mammals. In the brains of rhesus monkeys, grid-like cells were seen to activate?when the sitting primates just tracked their eyes across a room.?

One theory for how these compasses in the brain go about their space-coding business implicates a rhythmic, periodic pinging of neurons, called "theta oscillations."

"You're sitting [at] the stadium and everyone is talking together ? you hear a background hum, [but] if everyone starts chanting their name together, you hear a very clear up and down auditory output,"?Michael Hasselmo, a Boston University neuroscientist and co-author of one of the new studies, told NBC News. That's sort of how the neurons behave.?

Studied for the first time in flying fruit bats, these signature oscillations were absent, both in the flying animals and in the stimulated slices of tissue. Previously studied crawling bats didn't show evidence of the oscillations, either. "We did this in flight, and still we don't get those," Ulanovsky of the Weizmann Institute told NBC News.?

In the rat tissue, though? Those neurons were pinging away as expected. The fact that rats and rat brain tissue have place and grid cells, but not run by the usual rhythms, raises the possibility that navigation systems in rats and bats evolved separately but converged towards a similar goal, Hasselmo and his co-authors write in their paper.

Edvard Moser, who was not involved with either work but did early work on grid cells at the Kavli Institute for Systems Neuroscience in Norway, believes that the structure of place cells and grid cells in rats and bat brains are too similar for this to be the case.

Rather, the rhythmic dance of neurons could play a more general role in storing information. "It's important for blocking information and for defining sequences ... and making cells fire at the right order and at the right time," Moser told NBC News.?

More on navigation in mammals:?

Nidhi Subbaraman writes about science and technology. Follow her on Twitter and Google+.?

Source: http://feeds.nbcnews.com/c/35002/f/653377/s/2ae2a3f9/l/0Lscience0Bnbcnews0N0C0Inews0C20A130C0A40C180C1780A89670Escientists0Epuzzle0Eover0Ehow0Ebat0Ebrains0Eand0Erat0Ebrains0Ebuild0Emental0Emaps0Dlite/story01.htm

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A Fire-Starting Pen, For When Your Words Aren't Inflammatory Enough

They say the pen is mightier than the sword, but neither of those implements are really that effective when it comes to starting a campfire. So if survival and copious note-taking are high on your list when it comes to choosing office supplies, consider this tactical pen that hides a fire striker inside. More »
    


Source: http://feeds.gawker.com/~r/gizmodo/full/~3/QTMuDyJozUA/a-fire+starting-pen-for-when-your-words-arent-inflammatory-enough

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Researchers identify and block protein that interferes with appetite-suppressing hormone

Apr. 17, 2013 ? Ever since the appetite-regulation hormone called leptin was discovered in 1994, scientists have sought to understand the mechanisms that control its action. It was known that leptin was made by fat cells, reduced appetite and interacted with insulin , but the precise molecular details of its function -- details that might enable the creation of a new treatment for obesity -- remained elusive.

Now, University of Texas Medical Branch at Galveston researchers have revealed a significant part of one of those mechanisms, identifying a protein that can interfere with the brain's response to leptin. They've also created a compound that blocks the protein's action -- a potential forerunner to an anti-obesity drug.

In experiments with mice fed a high-fat diet, scientists from UTMB and the University of California, San Diego explored the role of the protein, known as Epac1, in blocking leptin's activity in the brain. They found that mice genetically engineered to be unable to produce Epac1 had lower body weights, lower body fat percentages, lower blood-plasma leptin levels and better glucose tolerance than normal mice.

When the researchers used a specially developed "Epac inhibitor" to treat brain-slice cultures taken from normal laboratory mice, they found elevated levels of proteins associated with greater leptin sensitivity. Similar results were seen in the genetically engineered mice that lacked the Epac1 gene. In addition, normal mice treated with the inhibitor had significantly lower levels of leptin in their blood plasma -- an indication that Epac1 also affected their leptin levels.

"We found that we can increase leptin sensitivity by creating mice that lack the genes for Epac1 or through a pharmacological intervention with our Epac inhibitor," said UTMB professor Xiaodong Cheng, lead author of a paper on the study that recently appeared on the cover of Molecular and Cellular Biology. "The knockout mice gave us a way to tease out the function of the protein, and the inhibitor served as a pharmacological probe that allowed us to manipulate these molecules in the cells."

Cheng and his colleagues suspected a connection between Epac1 and leptin because Epac1 is activated by cyclic AMP, a signaling molecule linked to metabolism and leptin production and secretion. Cyclic AMP is tied to a multitude of other cell signaling processes, many of which are targeted by current drugs. Cheng believes that understanding how it acts through Epac1 (and another form of the protein called Epac2) will also generate new pharmaceutical possibilities -- possibly including a drug therapy that will help fight obesity and diabetes.

"We refer to these Epac inhibitors as pharmacological probes, and while they are still far away from drugs, pharmaceutical intervention is always our eventual goal," Cheng said. "We were the first to develop Epac inhibitors, and now we're working very actively with Dr. Jia Zhou, a UTMB medicinal chemist, to modify them and improve their properties. In addition, we are collaborating with colleagues at the NIH National Center for Advancing Translational Sciences in searching for more potent and selective pharmacological probes for Epac proteins."

Other authors of the Molecular and Cellular Biology paper include research associates Jingbo Yan, Jingna Wei and Sonja Stutz, research scientists Fang C. Mei and Igor Patrikeev, graduate assistant Yaohua Hu, visiting physician Dapeng Hao, professors Massoud Motamedi and Kathryn A. Cunningham, associate professor Kelly T. Dineley and assistant professor Jonathan D. Hommel, all from UTMB. Authors from the University of California, San Diego include postdoctoral fellows Hongqiang Cheng and Dieu Hung Lao, and professor Ju Chen. This research was supported by the National Institute of General Medical Sciences.

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Journal Reference:

  1. J. Yan, F. C. Mei, H. Cheng, D. H. Lao, Y. Hu, J. Wei, I. Patrikeev, D. Hao, S. J. Stutz, K. T. Dineley, M. Motamedi, J. D. Hommel, K. A. Cunningham, J. Chen, X. Cheng. Enhanced Leptin Sensitivity, Reduced Adiposity, and Improved Glucose Homeostasis in Mice Lacking Exchange Protein Directly Activated by Cyclic AMP Isoform 1. Molecular and Cellular Biology, 2012; 33 (5): 918 DOI: 10.1128/MCB.01227-12

Note: If no author is given, the source is cited instead.

Disclaimer: This article is not intended to provide medical advice, diagnosis or treatment. Views expressed here do not necessarily reflect those of ScienceDaily or its staff.

Source: http://feeds.sciencedaily.com/~r/sciencedaily/health_medicine/genes/~3/bsMSlptIwdk/130417185906.htm

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Thursday, 18 April 2013

Cell-permeable peptide shows promise for controlling cardiovascular disease

Wednesday, April 17, 2013

Atherosclerosis ? sometimes called "hardening of the arteries" ? is a leading cause of death and morbidity in Western countries. A cell-permeable peptide containing the NF-?B nuclear localization sequence (NLS) shows promise as a potential agent in controlling the development of atherosclerotic disease. This study is published in the May 2013 issue of The American Journal of Pathology.

Atherosclerosis is a chronic inflammatory disease of the arterial and vascular wall. The objective of many therapeutic compounds is to modulate atherogenesis ? the process that leads to the formation of fatty tissue-containing plaques that stick to the cell wall. Numerous cellular and molecular inflammatory components are involved in the disease process, and uncontrolled activation of pro-inflammatory transcription factors, such as nuclear factor-B (NF-?B), plays a significant role. Several NF-?B inhibitors are in phase II-III clinical trials against various inflammatory diseases, but most cardiovascular research is still in the preliminary laboratory experimental phase.

Investigators in Spain, the United States, the United Kingdom, and Germany studied the anti-inflammatory and atheroprotective effects of a cell-permeable peptide containing the NF-?B NLS. In vitro tests clearly established that NLS peptide blocks the nuclear import of activated NF-?B and inhibits NF-?B activation in vascular cells. These findings were corroborated in vivo in ApoE knockout mice, an experimental model relevant to human atherosclerosis. In these experiments, the mice were fed a high-fat diet and treated with either NLS peptide or vehicle (control group).

The results showed that systemic administration of NLS peptide reduced the nuclear NF-?B activity in vascular smooth muscle cells (VSMCs) and macrophages of aortic plaques of mice. More importantly, NLS peptide inhibited lesion development in mice either at the onset of atherosclerosis (early treatment) or after the development of advanced plaques (delayed treatment), without affecting serum cholesterol levels. The results also demonstrated that NLS peptide alters plaque composition and inflammation in atherosclerotic lesions.

"The NF-?B system is a crucial factor regulating the expression of genes in different steps of the atherosclerotic process, from early phases characterized by lipid modification, chemotaxis, adhesion of leukocytes, monocyte differentiation, foam cell formation, and inflammatory cytokine expression to more advanced lesions involving cell death, migration and proliferation of VSMCs, and fibrous cap formation," explained lead investigator Carmen Gomez-Guerrero, PhD, of the Renal and Vascular Inflammation Laboratory, IIS-Fundaci?n Jim?nez D?az, Autonoma University, Madrid, Spain.

"Our study demonstrates that targeting NF-?B nuclear translocation hampers inflammation and atherosclerosis development and identifies cell-permeable NLS peptide as a potential anti-atherosclerotic agent," she said. "These properties make cell-permeable NLS peptide a promising prevention/intervention strategy to inhibit inflammation in cardiovascular diseases."

###

Elsevier Health Sciences: http://www.elsevierhealth.com

Thanks to Elsevier Health Sciences for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Source: http://www.labspaces.net/127787/Cell_permeable_peptide_shows_promise_for_controlling_cardiovascular_disease

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